【摘要】 目的　探讨人免疫缺陷病毒 (HIV)感染状态对间日疟严重程度的影响。方法　对不同感染状态 (CD4细胞水平在 12 17～ 15× 10 6/L)的 12例HIV阳性患者 (均签署知情同意书 )接种疟原虫诱发治疗性间日疟 ,10次高热阵发后用氯喹治愈疟疾 ,以体温曲线下的面积 (Tsq ,代表疟疾的临床严重程度 )和原虫密度与疟疾感染前患者CD4细胞计数作相关分析。结果　HIV患者在疟疾感染前的CD4细胞水平与感染后间日疟的临床严重程度 (Tsq)成正相关 ,r =0 819,P <0 0 5 ;与患者血中疟原虫密度也呈正相关 ,r =0 80 7,P <0 0 2。表明HIV感染引起的免疫缺陷越严重 ,则合并间日疟的临床严重程度和原虫血症就越轻。结论　研究结果提示HIV与疟原虫在人体内可能有相互拮抗或相互抑制的作用。更多还原

【Abstract】 Objective To explore the impact of human immunodeficiency virus(HIV) infection status on the severity of plasmodium vivax malaria.Methods Twelve patients with HIV infection(all signed informed consent) whose CD4 count baseline levels were 1 217～15×10 6/L were intravenously injected with plasmodia vivax to induce therapeutic malaria.Malaria was teminated with chloroquine after 10 fever episodes.Correlations of CD4 cell count baseline levels to the areas under temperature curves(Tsq,represents clinical severity of malaria)and to parasite densities were statistically analyzed.Results The CD4 count baseline levels of the HIV-infected subjects positively correlated to their clinical severities of malaria(r=0.819,P<0.05) and to their parasite densities of peripheral blood(r=0.807,P<0.02).These phenomena indicated that the HIV-positive patients had milder malarial symptoms and parasitemia with progressively lower CD4 cell baseline levels.Conclusion The results suggested that there was an antagonistic interaction between HIV and malarial parasite in human.更多还原