【摘要】 目的　探讨酒精依赖对大鼠组织损伤特征及敏感指标。方法　以市售北京红星牌二锅头 (含 5 2 %酒精 ) ,以 2 5 ,5 0 g/kg·体重剂量连续 6周灌胃形成大鼠酒精依赖 ,观察肝细胞损伤 (GPT活性增高 )程度与抗氧化防御和硒代谢关系。结果　 5 0g/kg·体重剂量组GPT活性与 2 5 g/kg·体重组和对照组比较 ,差异有极显著性意义 ,抗氧化防御和硒含量在血、肝及脑有非常明显的降低 (P均 <0 0 1) ,SOD活性在 2 5 g/kg·体重组呈现反跳。结论　肝是酒精性损伤的靶组织 ,LPO、GSH -Px和硒是酒精早期毒性损伤的敏感指标。更多还原

【Abstract】 Objective To approach the rat’s tissue injure feature and sensitive index of ethanol dependence.Methods To form ethhanol dependent rats by using 52% Erguotou (Beijing Hongxingpai) 2.5,5.0 g/kg·weight ingestion for 6 weeks and to observe the relationship between the degree of hepatocellular injure ( GPT activity increase ) and antioxidation defense and selenium metabolism.Results The GPT activity of 5.0 g/kg·weight dose group was remarkably higher than that of 2.5 g/kg·weight group and control group, the defense of antioxidation and selenium content in blood,liver and brain decreased remarkably ( P \-\{av\}<=0.01).The SOD activity in 2.5g/kg·weight group presented reversal.Conclusion The liver was the target tissue of ethanol toxic injure, LPO, GSH-Px and Se were sensitive index of alcohol’s early stage toxic injure.更多还原