【摘要】 目的　在条件Logistic回归分析的基础上 ,探讨Tourette综合征 (TS)危险因素的病因分值以及TS家族史与其他危险因素间的交互效应。方法　对温州地区 10 0例TS的现患病人作 1∶1配对病例对照研究。结果　多因素条件Logistic回归分析结果显示 :TS家族史、母亲孕早期受精神刺激、高热 (T >39℃ )是TS独立的危险因素 (OR =4 2 0～ 8 5 6,P <0 0 5 )。它们的病因分值分别是 0 161、0 135、0 12 6。分析TS家族史与高热 (T >39℃ )、母亲孕早期受精神刺激间的交互作用 ,其病因分值分别为 0 .62 9、0 0 69。交互作用指数是0 675、0 0 78。结论　TS家族史是TS的重要危险因素 ,尤其是在与高热 (T >39℃ )这一因素并存的情况下 ,增加TS发病的危险性。更多还原

【Abstract】 Objective The etiologic fraction and interaction of risk factors of Tourette syndrome(TS) were explored on the basis of the condional logistic regression analysis.Methods One hundred cases with TS and 100 controls were conducted by 1∶1 matched case-control study in Wenzhou.Results Multiple conditional logistic regression analysis showed that family history of TS,nocuous mental sitmulation during early pregnancy and highly fever (T>39℃) were the independent risk factors of TS.Etiologic fractions of the independent risk factors were 0.161,0.135,0 126 respectively.The interactions between family history of TS and risk factors which included highly fever (T>39℃),nocuous mental stimulation during early pregnancy were analysed.The result revealed that EF (AxB) (etiologic fraction attributable to interaction) were 0.629,0.069 respectively.The interaction index were 0.675,0.078 respectively.Conclusion These findings indicated family history of TS,particularly those having higly fever (T>39℃ ),increases the risk of TS.更多还原