【摘要】 目的　为了解急性脑梗死患者血清可溶性细胞间粘附分子 (s ICAM- 1)的变化及临床意义。方法　采用双抗体夹心 EL SA法测定了 6 8例脑梗死患者血清 s ICAM- 1,并与 31例 TIA患者和 30例正常人对照比较。结果　脑梗死患者 2 4小时内血清 s ICAM- 1水平明显高于 TIA和正常对照组 (P<0 .0 1)。大梗死灶组血清 s ICAM明显高于中梗死灶组和小梗死灶组。脑梗死患者血清 s ICAM- 1水平在脑梗死发生 2 4小时至 7天呈现上升趋势 ,7至 14天呈下降趋势。结论　 s ICAM- 1与急性脑梗死密切相关 ,参与了缺血后脑组织损伤的病理过程。实验证明 ,急性脑梗死早期大量白细胞聚集阻塞微血管 ,穿越内皮细胞进入组织 ,使局灶区组织受损。此时白细胞聚集与s ICAM- 1表达增强密切相关更多还原

【Abstract】 Objective To study the change of serum sICAM 1 in patients with acute cerebral infarction and its clinical significance. Methods The level of serum sICAM 1 was measured serially with two layer antibody sandwich ELISA in 68 patients with acute cerebral infarction,31 patients with TIA and 30 normal controls. Results It was shown that the level of serum sICAM 1 in patients with cerebral infarction 24 hours after the onset was higher than that in patients with TIA and normal controls(P<0.01).The level of serum sICAM 1 was significantly higher in the patients with large cerebral infarction than that in patients with medium and small cerebral infarction(P<0.05).The level of serum sICAM 1 in patients with cerebral infarction increased from 2 hours to 7 days and decreased from 7 days to 14 days. Conclusion These findings suggest that sICAM 1 be closely related to the development of acute cerebral infarction, it plays an important role in pathological procedure of cerebral damage after cerebral infarction.更多还原