【摘要】 目的 探讨重症肌无力患者胸腺切除术后影响远期生存的因素。方法 采用胸腺切除术治疗重症肌无力170例，对其中124例进行平均39.8个月的长期随访，运用统计软件对年龄、性别、病程、临床分型、病理类型等因素进行COX回归模型多因素分析。结果 影响远期生存的因素是胸腺的不同病理类型(胸腺增生、胸腺萎缩、良性胸腺瘤、恶性胸腺瘤)(P<0.05)，临床分型与病理类型具有相关性(P<0.01)。结论 重症肌无力胸腺切除术后远期生存率依胸腺增生、良性胸腺瘤、胸腺萎缩、恶性胸腺瘤等不同病理类型依次下降，临床分型在一定程度上可反映预后, 强调早期手术治疗和术后巩固治疗是提高远期生存率的关键。关键词： 重症肌无力； 胸腺切除术； 多因素分析更多还原

【Abstract】 Objective To investigate the factors affectin g the long term survival in Myasthenia Gravis (MG) after thymectomy. Methods Of 170 patients wer e performed by thymectomy, the long follow up was made in 124 patients and the following period were about 39.8 mon ths, an analysis was studied in comparison with age, sex, disease history, Osser man classification, pathologic types, using COX regression analysis model. Results The most important prognostic variables affecting the long term survival were the different pathologic types (P<0.05), and the Osserman classes were correlated with pathologic types (P<0.01). Conclusion The long t erm survival rate is calculated in all patients, it is decreased apparently in accordance with the thymic hyperplasia, benign thymoma, thymic atrophy, malignant thymoma, and the Osserman classes could also reflect the prognosis, early surgical treatment and further treatment postoperatively were t he keys to promote the survival rate.更多还原