【摘要】 目的　研究慢性氟中毒对神经细胞的作用机制及病理改变。方法　利用光电镜观察了慢性氟中毒大鼠脑组织的病理学改变。结果　慢性氟中毒大鼠脑组织光镜下的病理改变主要表现在海马 CA4区 ,以神经细胞核浓度、固缩、顶树突明显拉长为特点 ;电镜下的病理改变与光镜的改变一致。结论　慢性氟中毒鼠脑组织的病理改变具有选择性易损的特点 :最易受损的部位是海马 CA4区 ,与大鼠前脑缺血再灌流模型脑细胞病理改变相似更多还原

【Abstract】 Objective To study the pathology and the action mechanism of chronic fluorosis in neurones.Methods Method of morphologic:Using of light microscope and electric microscope observed changes of pathology of cerebral in chronic fluorosis.Results When the brain appeared chronic fluorosis,there are chromatin dense stain,pyknosis,and peak tree projecting elongate of neuronal cell nucleus in hippocampus CA 4 region;Changes of pathology of electric microscope and light microscope are consistent.Conclusions The change of pathology in cerebral of chronic fluorosis of rats has selective damage characteristics.The part of most liable to damage is the hippocampus CA 4 region.It is similitude following the change of pathology in the model of forebrain ischemic reperfusion of rats.更多还原