【摘要】 目的　观察京尼平苷预防给药对地鼠胆固醇结石形成的影响。方法　用高脂肪高蛋白致石饲料造成地鼠胆固醇结石模型 ,阳性对照药物熊去氧胆酸 80 mg/kg和京尼平苷 5 0 ,10 0 mg/kg ig,每天预防给药 ,给药 30 d后作胆囊内容物涂片检查观察地鼠的成石率 ,检测胆汁脂类成分计算胆汁成石指数。结果　模型组的成石率为 10 0 % ,成石指数 (L I)大于 1;京尼平苷 5 0和 10 0 m g/kg组的成石率分别为 40 % (P<0 .0 5 )和 2 5 % (P<0 .0 1) ,L I均小于1,熊去氧胆酸组的成石率与 L I与京尼平苷 10 0 mg/kg组相近。结论　京尼平苷对地鼠胆固醇结石的形成可能具有抑制作用更多还原

【Abstract】 Object To study the effect of geniposide in the prophylaxis of cholesterol calculus formation in gall ducts of Syria Golden hamster Methods Experimental hamster models with cholesterol calculus was prepared by feeding lithogenous diet with high content of fat and protein for 30 d with simultaneous administration of geniposide at doses of 50 and 100 mg/kg/d ig or ursodeoxycholic acid as positive control at the dose of 80 mg/kg/d After the last dosage, the hamsters were sacrificed and their gallstone formation rate were determined by examining the smear of gallbladder content and their lithogenous index (LI) were calculated from the assay of lipoid substances in bile such as cholesterol (Ch), bile acids (Bs) and phospholipid (Pl) Results The gallstone formation rate in the blank model group, geniposide 50 and 100 mg/kg were 100%, 40% (P<0 05), 25% (P<0 01) respectively, while LI in the blank model group was more than 1, the LI of all other groups were less than 1 Conclusion Geniposide may prevent the formation of cholesterol calculus in gall ducts更多还原