【摘要】 目的　研究槐胺碱 (SA)对移植排斥反应的影响并探讨其发生机制。方法　以同种皮肤移植大鼠作为动物模型 ,免疫荧光浊测定 T淋巴细胞及其亚群数量 ;MTT比色法测定 T淋巴细胞增殖反应。结果　 SA减少 CD3、CD4细胞数 ,降低 CD4/ CD8,抑制 T淋巴细胞的增殖 ,延长移植物存活时间。结论　 SA对移植排斥反应有抑制作用 ,此作用与其减少 T淋巴细胞数量并抑制 T淋巴细胞功能有关更多还原

【Abstract】 Object In order to obtain further evidence of therapeutic efficacy of sophoramine (SA) *, its effect on transplantation rejection was studied with simultaneous exploration of its mechanism of action Methods Number of T lymphocyte and its sub sets of skin allografted rat model were determined by immunofluorescence technique, and proliferation of T lymphocyte was assessed by thiazolyl blue (MTT) assay Results SA reduced the CD 3 and C 4 cell counts, lowered CD 4/C 8 ratio, inhibited T lymphocyte proliferation and prolonged the survival time of skin allografted rat Conclusion SA could inhibit transplantation rejection by inhibiting the function of T lymphocyte with simultaneous reduction of lymphocyte count更多还原