【摘要】 目的　观察总丹酚酸 (Sal)对脑缺血再灌注损伤的保护作用。方法　采用小鼠和大鼠脑缺血再灌注模型。结果　在小鼠和大鼠全脑缺血再灌注模型上 ,Sal10 ,2 0 m g/ kg iv及 Sal5 ,10 mg/ kg iv可显著提高脑组织乳酸脱氢酶 (L DH)及超氧化物歧化酶 (SOD)活性 ,明显降低丙二醛 (MDA)含量。在大鼠局灶性脑缺血 2 h再灌注 2 4h模型上 ,Sal 5 ,10 mg/ kg iv可明显缩小梗死灶面积 ,改善神经功能缺损 ,并显著抑制缺血脑组织中 L DH和 SOD活性降低 ,减少 MDA的过量产生。结论　 Sal对小鼠和大鼠脑缺血再灌注损伤有显著保护作用 ,其机制与其抗氧自由基作用有关更多还原

【Abstract】 Object It was reported that salvianolic acid A from Salvia miltiorrhiza Bge could improve memory dysfunction of mice with cerebral ischemia reperfusion injury The effects of total salvianolic acids (Sal), including salvianolic acid A and B, rosmaric acid and protocatechic aldehyde was now studied to observe its effect on cerebral ischemia reperfusion injury in hope of obtaining a preliminary view on its mechanism of action Methods The effects of Sal on lactic dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) of cerebral ischemia reperfusion injured mouse and rat models were observed Results Sal 10, 20 mg/kg iv and 5, 10 mg/kg iv could markedly increase the activities of LDH and SOD and lower the production of MDA in the injured cerebral tissue On focal cerebral ischemia reperfusion injured rat, 24 h reperfusion after 2 h ischemic injury, 5, 10 mg/kg iv Sal could decrease infarct size, ameliorate neurological deficit with obvious inhibition of the decrease of LDH and SOD activities and the over production of MDA Conclusion Sal showed obvious protective effects on cerebral ischemia reperfusion injuries of mice and rats via attenuating oxygen free radical更多还原