【摘要】 目的 :观察不同剂量稀土元素 -镧对大鼠睾丸 7型水通道 (aquaporin 7,AQP 7)基因表达水平的影响。方法 :取硝酸镧 [La(NO3) 3]灌胃 6个月大鼠的睾丸组织提取总RNA进行Northernblot分析。结果 :低剂量La(NO3) 3(0 1mg/kg)抑制大鼠睾丸AQP 7的mRNA表达 ,而高剂量La(NO3) 3(2 0mg/kg)的作用与对照组比较无明显差别。结论 :大鼠睾丸内可见AQP 7mRNA的表达 ;硝酸镧能影响大鼠睾丸AQP 7mRNA表达的强度更多还原

【Abstract】 AIM: To find out whether different dosage of rare earth element-lanthanum can influence the expression of aquaporin 7(AQP 7) in the testis of rats. METHODS:Rats were fed with lanthanum nitrate [La(NO 3) 3] and killed 6 months later. Testes were then removed immediately to extract total RNA. Northern blot analysis is performed finally. RESULTS:0.1 mg/kg La(NO 3) 3 depressed the expression of AQP 7 in rat testis, while 20 mg/kg La(NO 3) 3 had no significant effect on it. CONCLUSION: AQP 7 expession is found in the rat testis; La(NO 3) 3 can depress the expression of AQP 7 in the rat testis.更多还原