【摘要】 目的 :　观察不同剂量核桃油和核桃油加维生素 E(核桃油复合 VE)对大鼠血脂和动脉粥样硬化的作用。方法 :　 80只 Wistar大鼠 ,雌雄各半 ,用高脂饲料制作动物高脂血症和动脉粥样硬化模型 ,然后将动物分为 5组 ;核桃油低、高剂量组 ,0 .3g/kg bw、1 g/kg bw;核桃油复合VE(核桃油和 VE的比例为每 3g核桃油中含 0 .2 g VE)低、高剂量组 ,0 .3g/kg bw、1 g/kg bw;对照组以 1 ml/kg生理盐水灌胃 ,实验各组均每天灌胃油剂一次 ,连续 4w。结果 :　 1 .核桃油和核桃油复合 VE对大鼠摄食及生长发育均无影响。 2 .核桃油能明显降低的雄性高脂血症大鼠血中的总胆固醇 ( TC)、甘油三酯 ( TG)、升高载脂蛋白 AI( Apo- AI) ,明显降低雌性高脂血症大鼠血中的 TG水平 ,升高其 Apo- AI。 3.核桃油复合 VE能显著降低雄性高脂血症大鼠血中的 TC、低密度脂蛋白胆固醇 ( LDL- C) ,高剂量核桃油复合 VE还能升高其血浆高密度脂蛋白胆固醇 ( HDL- C)、提高动物的抗动脉粥样硬化指数 ( AAI) ;对雌性大鼠除与雄性大鼠有类似的作用之外 ,还能明显降低血中TG和 Apo- B水平。结论 :　核桃油和核桃油复合 VE均有不同程度的降低大鼠血脂及改善动脉粥样硬化的作用更多还原

【Abstract】 Objective: To demonstrate the effects of walnut oil and walnut oil VE complex on plasma lipid and atherosclerosis. Methods: 80 Wistar rats (half female and half male) were given high fat diet to induce the hyperlipidemia model. Then the animals were divided into 5 groups:walnut oil 1g/kg group, walnut oil 0.3g/kg group, walnut oil VE complex 1g/kg group, walnut oil VE complex 0.3g/kg group and control group. The oil was given by gavage one time a day for 4 w respectively. Results: 1.Both walnut oil and walnut oil VE complex didnt affect the growth and development of rats. 2.Walnut oil significantly lowered plasma TC,TG, and elevated Apo AI in male rats, significantly lowered TG,Apo B and elevated Apo AI in female rats. 3.Walnut oil VE complex significantly lowered plasma TC,LDL C, elevated HDL C and Apo AI in male rats; in female rats, in addition to the similar effects in male rats, walnut oil VE complex significantly lowered TG, Apo B, though no effect on HDL C. Conclusion: Both walnut oil and walnut oil VE complex have the protective effects on hyperlipidemia and atherosclerosis in rats.更多还原