【摘要】 设计合成了 1 1种 B环上含不同性质取代基的新型黄烷酮衍生物 ,采用核磁共振氢谱及元素分析对所合成的化合物进行了结构表征 .初步杀菌活性测试结果表明 ,所合成的化合物均表现出不同程度的杀菌活性 ,其中化合物 3 b(3 -硝基黄烷酮 )在质量浓度为 5 0、1 0和 1 μg/L下对水稻纹枯病、棉花枯萎病、苹果轮纹病、小麦赤霉病以及芦笋褐斑病均表现出 1 0 0 %的抑制活性 .初步构效关系研究表明 ,B环取代基的电性性质及疏水性质对化合物的杀菌活性有重要影响 .更多还原

【Abstract】 In order to study the relationship between the fungicidal activity and the substituents on B cycle of flavanone derivatives, a series of flavanone derivatives containing various subtituents on B cycle were designed and synthesized starting from 2 hydroxylacetophenone. The structures of all compounds synthesized were confirmed by spectroscopic methods and microanalyses. Preliminary bioassays indicated that some compounds e.g. 3b, 3e, 3h and 3j showed excellent fungicidal activities against Rhizoctonia solani, Fusarium oxysporum, Physalospora piricola, Fusarium gramineum and Cercospora beticola at the dosage of 50 μg/L. Preliminary structure activity relationship analysis indicated that the hydrophobicity and electronic effect of the substituents on B cycle have important effect on the fungicidal activity.更多还原