【摘要】 目的通过霉酚酸酯(MMF)在难治性肾病综合征的临床疗效观察,探讨MMF治疗难治性肾综的适应症。方法经肾活检及临床诊断为难治性肾综患者21例,观察MMF治疗后第4周、8周、12周及16周各项临床指标变化,对其疗效进行评价。结果 MMF能有效降低难治性肾综患者24小时尿蛋白总量(P<0.01),血清白蛋白水平上升(P<0.01)。总有效率为85.7％。MCD和MesPGN对MMF反应良好(有效率100％),FSGS和MN疗效较差,3例(3/5)无效。所有病例对MMF有良好耐受性。结论 MMF能有效缓解难治性肾综,疗效良好。更多还原

【Abstract】 Objective To investigate the effect of mycophenolate mofetil (MMF) in treatment refractory nephropathy syndrome.Methods The 21 refractory nephropathy syndrome patients were diagnosed by renal biopsy, and received MMF therapy.The clinical data was observed in 4th week, 8th week, 12 th week and 16th week.Results The proteinuria were decreased significandy after received MMF therapy in refractory nephropathy syndrome. Serum albumin were increased significandy ( P < 0.01) .Total efficiency was 85.7% .There were a significance effects in MCD and MesPGN, but not in FSGS and MN. No serious side effects was observed. Conclusion MMF is a efficient medicine to treat refractory nephropathy syndrome.更多还原