【摘要】 在家兔颈总动脉球囊损伤模型上 ,观察卡托普利 (Captopril)对术后 2周血浆内皮素 (ET1 )、血管内膜增殖细胞核抗原 (PCNA)阳性表达率、血管内膜厚度的影响。结果表明 :Captopril能显著降低球囊损伤后家兔血浆 ET1 水平及血管内膜 PCNA阳性表达率 (P <0 .0 1) ;与剥脱对照组相比 ,Captopril组血管内膜厚度及管腔狭窄率明显降低 (P <0 .0 1)。提示 :Captopril能抑制血管损伤后内膜的增生 ,可能是通过降低 ET1 水平及抑制平滑肌细胞增殖实现的 ,为 Captopril应用于动脉粥样硬化及经皮冠状动脉成形术后再狭窄的治疗提供一定的依据更多还原

【Abstract】 To study the effect of Angiotension converting enzyme inhibitor captopril on the arterial intimal hyperplasia after ballon injury was administered. Eighteen rabbits were divided into three groups at random; sham operation (S) group, control(Con) group and captopril(cat) group (each group n=6). Captopril was given to 6 rabbits (10 mg/kg·d -1 ,po) from 2 days before the right carotid arteries were injured by 3.6 F ballon catheter to 14 days after injury. The control group (6 rabbits) underwent the same balloon injury but no medicine was administered. Results showed:1.Lever of plasma ET 1 14 days after injury in Cat group was significantly lower than that of Con group; Con group was significantly higher than that of S Group(P<0.01,respectively).2.Proliferation Index PCNA:Con group and Cat group were both higher than that of S group(P<0.01,respectively); Cat group was significantly lower than that of Con group(P<0.01,respectively). 3.Mean thickness and extent of lumen stenosis:Cat group was significantly lower than Con group (P<0.01).Conclusion:Captopril inhibits intimal thickening after ballon injury.更多还原