【摘要】 目的　研究 2 0 (R) 人参皂苷Rg3(GRg3)人体药代动力学。 方法　高效液相色谱 -紫外检测法。结果8名健康志愿者单剂量口服 3 2mg·kg-1GRg3 ,其药时曲线符合口服吸收有滞后时间的二房室模型 ,Tmax为 (0 6 6± 0 10 )h ,Cmax为 (16± 6 )ng·mL-1,T1/ 2α为 (0 46± 0 12 )h ,T1/ 2 β为 (4 9± 1 1)h ,T1/ 2 (Ka) 为 (0 2 8± 0 0 4)h ,AUC0 -∞ 为 (77± 2 6 )ng·mL-1·h ;6名健康志愿者单剂量口服 0 8mg·kg-1GRg3 ,由于血药浓度低 ,可测数据点少 ,未进行模型模拟 ;两组给药剂量与相应Cmax实测值比较 ,二者成正比关系。结论　本品口服吸收快 ,消除也较快 ,但血药浓度很低。在所试剂量范围内 ,GRg3属一级动力学吸收、消除过程。更多还原

【Abstract】 AIM To study the pharmacokinetics of 20( R ) ginsenoside Rg3 (GRg3) in human. METHODS High performance liquid chromatography ultraviolet detection method was used in this study. RESULTS The pharmacokinetics of GRg3 in 14 healthy volunteers were investigated. After a single oral dose of 3 2 mg·kg -1 in 8 male volunteers, the plasma concentration time course fitted well to a two compartment open model, with the following pharmacokinetic parameters: T max (0 66±0 10) h, C max (16±6) ng·mL -1 , T 1/2α (0 46±0 12) h, T 1/2β (4 9±1 1) h, T 1/2(Ka) (0 28±0 04) h, AUC 0-∞ (77±26) ng·mL -1 ·h. No kinetic analysis was made after an oral dose of 0 8 mg·kg -1 GRg3 in 6 other volunteers because of the low concentration, but a good correlation between C max and dosage of the two groups was found. CONCLUSION The absorption of GRg3 was rapid in man, and its elimination was rapid after oral administration of ginsenoside Rg3. The pharmacokinetic results shows that it exhibited first order kinetic characteristics.更多还原