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白三烯拮抗剂ONO-1078对小鼠局灶性脑缺血的保护作用

PROTECTIVE EFFECT OF ONO-1078, A LEUKOTRIENE ANTAGONIST, ON FOCAL CEREBRAL ISCHEMIA IN MICE

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【作者】 曾玲晖张纬萍王仁定王苹丽魏尔清

【Author】 ZENG Ling hui, ZHANG Wei ping, WANG Ren ding, WANG Ping li, WEI Er qing (Laboratory of Neurobiology, Medical School, Zhejiang University, Hangzhou 310031, China)

【机构】 浙江大学医学院神经生物学实验室!浙江杭州310031

【Abstract】 AIM To determine whether ONO 1078 {pranlukast, 4 oxo 8 [p (4 phenylbutyloxy) benzoyl amino] 2 (tetrazol 5 yl) 4H 1 benzopyran hemihydrate}, a potent leukotriene antagonist, has protective effect on focal cerebral ischemia in mice. METHODS Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice. ONO 1078 (0 01, 0 05, 0 10 mg·kg -1 ), dexamethasone (0 5 mg·kg -1 ), nimodipine (0 2 mg·kg -1 ) or saline (control) were injected ip once daily for 3 days, and 30 min before MCA occlusion. Twenty four hours after cerebral ischemia, the neurological scores were evaluated, infarct volumes and areas of the right and left cerebral hemispheres were measured by computer imaging analysis. RESULTS ONO 1078, dexamethasone and nimodipine reduced the neurological scores. ONO 1078 and dexamethasone reduced the ratio of right/left hemisphere area, indicating inhibition of brain edema, while nimodipine showed no effect. ONO 1078 dose dependently reduced infarct size, and dexamethasone and nimodipine showed the same effect. CONCLUSION ONO 1078 showed protective effect on focal cerebral ischemia. This may represent a novel approach to the treatment of acute cerebral ischemia.

【基金】 国家自然科学基金资助项目!(39770 2 70 )
  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,2001年02期
  • 【分类号】R96
  • 【被引频次】27
  • 【下载频次】82
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