【摘要】 目的　研究微球的粒子大小和超高速氦气气流的压力对释放固体微球经皮给药吸收过程的影响。方法利用氦气的超高速流体通过对固体粒子进行加速的方法 ,将药物粉末透过角质层释放到表皮和真皮表面 ,将固体药物粉末通过皮肤释放到体内。结果　药物导入率依赖于超高速氦气气流的压力和微球的粒子大小 ,且生物利用度和最高血中浓度也依赖于超高速氦气气流压力的影响。结论　本系统可用于固体药物粉末、多肽类药物、高分子药物以及蛋白性药物的经皮给药更多还原

【Abstract】 AIM To investigate the effect of particle size and high speed flow of helium gas on the systemic absorption of indomethacin using a needle less injection system. METHODS Poly L lactic acid microspheres containing indomethacin was prepared by the o/w solvent evaporation technique. After anesthetizing the male hairless rat, microspheres filled in the tube cartridge was accelerated by a stream of helium gas at various velocity in the Helios TM gun system, and then was introduced to the abdominal skin. RESULTS Introduction of indomethacin to the hairless rat skin was proportionally increased with enhancing the helium pressure (supersonic flow). Bioavailability and C max were also dependent on the helium pressure. CONCLUSION This method can be used to deliver the powered drug and/or microparticulate systems into the skin tissues and the systemic circulation.更多还原