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M3受体激动剂对大鼠和家兔心脏血流动力学的影响

CARDIAC HEMODYNAMIC EFFECTS OF M3 RECEPTOR AGONIST ON RAT AND RABBIT HEARTS

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【作者】 刘艳王玥马满玲张妍李厚伟陈庆文杨宝峰

【Author】 LIU Yan 1, WANG Yue 1, MA Man ling 2, ZHANG Yan 1, LI Hou wei 1, CHEN Qing wen 1, YANG Bao feng 1 (1. Department of Pharmacology, Harbin Medical University, Harbin 150086, China; 2. Department of Pharmacy, the First Affiliated Hospital o

【机构】 哈尔滨医科大学药理教研室哈尔滨医科大学附属一院药剂科!黑龙江哈尔滨150086

【摘要】 目的 研究胆碱对大鼠和家兔心脏M3 受体的激动作用及其引起的血流动力学改变。方法 经右颈总动脉插管入左心室 ,用八导生理记录仪测定大鼠和家兔血流动力学参数。结果 iv胆碱 10mg·kg-130s后 ,大鼠的心率 (HR)比基础值明显降低 ,10min后恢复。±dp/dtmax和LVSP于给药 10min后明显降低。上述抑制作用可被选择性M3 受体阻断剂 4 DAMP 0 12mg·kg-1所对抗。家兔iv胆碱 5mg·kg-1后 1min ,心率明显降低 ,此作用可被 4 DAMP所对抗。±dp/dt,LVSP亦有下降趋势 ,但无统计学差异。M3 受体阻断剂 4 DAMP对大鼠和家兔血流动力学无明显影响 ,但预先给药可阻断胆碱引起的血流动力学变化。结论 胆碱通过激动心脏M3 受体产生负性肌力和负性频率作用

【Abstract】 AIM To study the activation of choline on M 3 R in heart and observe the hemodynamic changes of rat and rabbit. METHODS A cardiac catheter was inserted into the left ventricular cavity via the right carotid artery, then the HR, LVSP, LVEDP, and ±dp/dt were measured using a polygraph system. RESULTS Choline was shown to decrease the hemodynamic assessments, such as HR, +dp/dt, LVSP and LVEDP. while the M 3 R antagonist 4 DAMP (4 diphenylacetoxy N methylpiperidine methiodide) showed little effect on these assessments. It was found to reverse the hemodynamic effects of choline. CONCLUSION M 3 receptor agonist can produce negative inotropic and chronotropic effects on the heart of rat and rabbit.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,2001年02期
  • 【分类号】R96
  • 【被引频次】15
  • 【下载频次】166
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