【摘要】 目的　研究胆碱对大鼠和家兔心脏M3 受体的激动作用及其引起的血流动力学改变。方法　经右颈总动脉插管入左心室 ,用八导生理记录仪测定大鼠和家兔血流动力学参数。结果　iv胆碱 10mg·kg-130s后 ,大鼠的心率 (HR)比基础值明显降低 ,10min后恢复。±dp/dtmax和LVSP于给药 10min后明显降低。上述抑制作用可被选择性M3 受体阻断剂 4 DAMP 0 12mg·kg-1所对抗。家兔iv胆碱 5mg·kg-1后 1min ,心率明显降低 ,此作用可被 4 DAMP所对抗。±dp/dt,LVSP亦有下降趋势 ,但无统计学差异。M3 受体阻断剂 4 DAMP对大鼠和家兔血流动力学无明显影响 ,但预先给药可阻断胆碱引起的血流动力学变化。结论　胆碱通过激动心脏M3 受体产生负性肌力和负性频率作用更多还原

【Abstract】 AIM To study the activation of choline on M 3 R in heart and observe the hemodynamic changes of rat and rabbit. METHODS A cardiac catheter was inserted into the left ventricular cavity via the right carotid artery, then the HR, LVSP, LVEDP, and ±dp/dt were measured using a polygraph system. RESULTS Choline was shown to decrease the hemodynamic assessments, such as HR, +dp/dt, LVSP and LVEDP. while the M 3 R antagonist 4 DAMP (4 diphenylacetoxy N methylpiperidine methiodide) showed little effect on these assessments. It was found to reverse the hemodynamic effects of choline. CONCLUSION M 3 receptor agonist can produce negative inotropic and chronotropic effects on the heart of rat and rabbit.更多还原