【摘要】 在高效液相色谱中以蛋白质作手性固定相进行药物拆分已被广泛采用 ,因为这类手性固定相能提供多种作用和识别位点。本文综述了蛋白质类手性固定相的性质及其在药物拆分中的应用 ,重点讨论了各种影响药物拆分的因素 ,如固定相状况、流动相的 p H值、有机改性剂、色谱柱温度等。更多还原

【Abstract】 Proteins as chiral stationary phases(CSP) in high performance liquid chromatography were widely used in the resolution of enantiomic drugs, for CSP can provide multiple interactions and multiple recognition sites. In this paper, the characters and applications of proteins as CSP in enantiomic drug resolution were reviewed, and the factors influenting the results of drug resolution, such as state of stationary phase, pH value of mobile phase ,organic modified agent and temperature of the column were emphasized.更多还原