【摘要】 目的 :综合和了解米非司酮治疗子宫肌瘤中文文献中不良反应研究结果。方法 :全面检索有关中文文献 ;应用定性综述的方法分析和综合研究的主要结果。结果 :搜集到 2 4篇文献的全文 ,占可能达标文献的87%。 9篇文献明示进行不良反应的观测 ,18篇文献较为详细地介绍了不良反应的结果 ,未见文献制定或标示了判定标准 ;发生频度最高的反应是潮热多汗 (138/ 80 5 ) ,最严重的反应似为ALT升高 ;3篇文献指出无因过敏或不良反应而停药的情况 ,5篇文献强调疗程结束后不良反应消失。结论 :有关文献对不良反应的观测比较重视 ,但观测方式似不够严谨 ;米非司酮治疗子宫肌瘤时的不良反应不太严重 ,不影响治疗 ,且停药后消失 ,但对于ALT升高和米非司酮的中长期安全性需要更为严格的研究更多还原

【Abstract】 To review the research results of adverse drug reaction(ADRs) of mifepristone in the treatment of hysteromyoma in Chinese literature, all the Chinese literature were comprehensively retrieved and were analyzed and summarized by using the qualtiative review technique. 24 full text papers were found. Among them 9 papers clearly presented the observation of ADRs and 18 papers gave detailed results of ADRs. No paper gave of formulated criteria for the judgement. The most frequent reaction was profuse sweating and the most serious reaction was elevation of ALT. 3 papers showed no withdrawal of treatment due to allergy or side effects. 6 papers showed that ADRs disappeared after conclusion of the treatment. It is concluded that some papers attach great importance to the monitoring of the ADRs but the judgement was not strictly based on well defined criteria. The ADRs of mifepristone was not serious and did not affect the treatment and disappear after discontinuation of the medication. More study should be conducted on the increased ALT caused by mifepristone and its middle and long term safety.更多还原