节点文献

顶空气相色谱法测定几丁糖酯中溶剂残留

Determination of Residual Solvent in Chitosan Ester by Headspace Gas Chromatography

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 吕志华王远红赵峡夏蕴秋徐家敏

【Author】 L Zhi-hua,WANG Yuan-hong,ZHAO Xia,XIA Yun-qiu and XU Jia-min (Institute of Foods and Drugs,Ocean University of Qingdao,Qingdao\ 266003)

【机构】 青岛海洋大学海洋药物与食品研究所!青岛266003青岛海洋大学!2000届毕业生

【摘要】 目的 :建立顶空气相色谱法分析几丁糖酯中溶剂残留。方法 :采用水溶液顶空和固体顶空 2种气相色谱法 ,用AC -2 0石英毛细管色谱柱 ,以正丙醇为内标进行定量。结果 :水溶液顶空气相色谱法乙醇的线性范围为 8~ 192 μg·mL-1,丙酮的线性范围为 2~ 6 4μg·mL-1;方法的回收率为乙醇 10 3 3% ,丙酮 95 71% ,RSD均为 4 2 % ;最低检测限溶液中乙醇为 4μg·mL-1,丙酮为 1μg·mL-1。固体顶空气相色谱法乙醇的线性范围为 0 16~ 2 4μg·mL-1,丙酮的线性范围为 0 16~ 1 6 μg·mL-1;方法的回收率为乙醇 96 32 % ,丙酮 10 2 1% ,RSD分别为 3 5 %和 2 6 % ;最低检测限乙醇为 0 12 μg·g-1,丙酮为 0 0 6 μg·g-1。结论 :此 2种方法简单 ,准确 ,灵敏度高 ,经显著性检验二者无显著性差异。

【Abstract】 Objective:To develop headspace gas chromatography for the determination of residual solvent in chitosan ester.Methods:Using two methods which were solution headspace analysis and solid headspace analysis with AC-20 capillary column and n -propanol as internal standard.Results:In solution headspace analysis,the linear concentration region of ethanol was 8~192 μg·mL\+\{-1\},acetone was 2~64 μg·mL\+\{-1\},the relative recovery of ethanol was 103 3%,acetone was 95 71%,with RSD 4 2% respectively,the lowest detective concentration was 4 μg·mL\+\{-1\} for ethanol and 1 μg·mL\+\{-1\} for acetone.In solid headspace analysis,the linear concentration region of ethanol was 0 16~2 4 μg·mL\+\{-1\},acetone was 0 16~1 6 μg·mL\+\{-1\},the relative recovery of ethanol was 96 32%,acetone was 102 1%,with RSD 3 5% and 2 6% respectively,the lowest detective concentration was 0 12 μg·g\+\{-1\} for ethanol and 0 06 μg·g\+\{-1\} for acetone.Conclusion:These two methods are simple,accurate and sensitive,there is no remarkable difference between these two methods.

【基金】 国家“8 6 3”资助项目 (819-0 7-0 3)
  • 【文献出处】 药物分析杂志 ,Chinese Journal of Pharmaceutical Analysis , 编辑部邮箱 ,2001年04期
  • 【分类号】R927.2
  • 【被引频次】31
  • 【下载频次】216
节点文献中: 

本文链接的文献网络图示:

本文的引文网络