【摘要】 目的　探讨大肠良恶性病变中nm2 3-H1的表达及与大肠癌浸润转移的关系。方法　应用ABC免疫组化法检测 80例大肠正常黏膜、腺瘤及癌中nm2 3-H1的表达情况。结果　大肠癌组织中nm2 3-H1阳性表达率为6 6 7% ;nm2 3-H1表达在正常黏膜、腺瘤及大肠癌各组间虽呈下降趋势 ,但无显著性差异 (P >0 0 5 ) ;其阳性表达与癌组织的分化程度、有无淋巴结转移及患者的生存时间等方面均有明显的相关关系 (P <0 .0 5 )。结论　nm2 3-H1可能在大肠癌的演进过程中起重要作用 ,nm2 3-H1基因的低表达与大肠癌发生有关 ,并可能与癌的进展、转移及预后密切相关更多还原

【Abstract】 Objective\ To investigate the expression of nm23-H 1 in human benign and malignant colorectal lesions and the relationship between invasion,metastasis in colorectal carcinoma.Methods\ The expression of nm23-H 1 were determined by ABC immunohistochemical technique in 80 cases human colorectal carcinoma,and compared with that in adenoma and normal mucus.Result\ Positivity expression rates of nm23-H 1 were 66.7% in colorectal carcinoma.No significant difference of the expression of nm23-H 1 in normal mucus,adenoma and cancerous tissue (P>0.05).The positive rates of nm23-H 1 expression in different pathological grading,lymph node metastasis and post-operative survival (3 years) were showed significant difference (P<0.05).Conclusions\ It is suggested that the deletion of nm23-H 1 low expression might play an important role in the carcinogenesis,development,metastasis and prognostic value of human colorectal carcinoma.更多还原