【摘要】 目的 :通过研究肝炎肝硬化病人胃动力改变与胃动素 (MTL)检测之间关系 ,以探讨肝硬化病人消化功能紊乱的发生机制、诊断及治疗方法。方法 :选择 1998年 11月～ 2 0 0 0年 2月资料完整病人 5 1例。通过超声波测空腹胃排空时间、胃电图测胃节律功能、用Child分级来判定肝损伤程度 ,用放射免疫法检测空腹胃动素水平。促进胃动力药物用普瑞博思。结果 :肝硬化组与对照组相比 ,肝功损伤程度与胃节律紊乱、上消化道不适症状、以及胃排空延迟之间均呈正相关。肝硬化组血清胃动素浓度明显高于对照组。促动力药物可改善胃动力异常 ,但胃动素水平无变化。结论 :肝炎肝硬化病人存在胃运动功能障碍 ,与肝功能损伤程度呈正相关。推测这种障碍与肝硬化病人胃对胃动素的敏感性下降有关。通过测定胃动素可判定肝损伤、胃排空延迟及胃节律紊乱程度。促胃动力药物治疗有效更多还原

【Abstract】 Objective:We clarify the relationship between dysfunction of gastric motility and the plasma motilin,in order to study the pathogenesis,diagnosis and therapy of the hepatocirrhosis with dyspepsia.Methods:The liquid gastric emptying (GE),electrogastrograpgy(EGG) and plasma motilin were examined in 51 patients with hepatocirrhosis.Results:The dysfunction of gastric motility is associated with the liver function,gastric rhythm and upper gastrointestinal symptom.The plasma motilin concentration increased significantly in patients with hepatocirrhosis as compared with that of controls (P<0.01).The sorbefacient prokinetic drug (prepulsid) can improve the function of gastric power,but the lever of motilin no change.Conclusion:The patients with hepatocirrhosis have the dysfunction of gastric motility,and gastric emptying delayed,and there is a relation between GE and the liver function.We evaluate that this disorder is associated with the low sensitivity about stomach to the plasma molitin in this case.We can judge the degree of the liver damage\,gastric emptying delayed.gastric rhythm by testing the gastric motilin.Drug can deal it.更多还原