【摘要】 目的探讨不同增生性玻璃体视网膜病变（ＰＶＲ）的增殖特征。方法采用５种特异性抗体对１２例ＰＶＲ膜样本进行免疫组织化学研究。结果成纤维细胞、神经胶质细胞为参与ＰＶＲ膜的主要细胞成分，视网膜色素上皮细胞（ＲＰＥ）、巨噬细胞、纤维连接蛋白和新生血管也参与了ＰＶＲ的病理过程。结论新生血管主要参与了增生性视网膜血管病变的病理过程。增殖膜中增殖的细胞、细胞外基质和血管成分参与了ＰＶＲ的病理过程并起着不同的作用。更多还原

【Abstract】 Objective To evaluate the characteristics of proliferation in different proliferative vitreoretinopathy(PVR). Method Five specific antibodies cytokeratin(CK), CD68, fibronectin(FN ), factor Ⅷ (F Ⅷ ) and actin were used respectively. The specimens from 12 cases with different PVR were studied by immunohistochemical method. Results Fibroblasts and glial cells were the main cellular components of the PVR membranes, retinal pigment epithelium(RPE ) cells, macrophages, fibronectin and neovasculature also took part in the pathological process of PVR. PVR membranes could be divided into fibrovascular membrane and fibrous membrane. Conclusion Neovasculature plays an important role in the pathological process of retinal neovascular diseases such as PVR and Eales diseases. There were interactions among the cellular components,the extra cellular matrix, the vascular elements and the growth factors in the PVR membrances. Each of the membrane components plays a different role in the development of PVR.更多还原