【摘要】 首次报道柔弱短指软珊瑚 (SinulariatenellaLi.)的化学成分。从中国南海采集的柔弱短指软珊瑚中分离得到 5个西松烯二萜内酯。根据波谱数据分析 ,推导出它们的结构 :dihydroflexibilide(1) ,flxibilide(2 )sinulariolide(3) ,(1R ,4R ,5R ,8S ,9S ,12S ,13S) 9 acetoxy 5 ,8∶12 ,13 diepoxy cembr 15 (17) en 16 ,4 olide(4 )和 (1R ,4R ,5S 12S ,13S) 5 acetoxy 12 ,13 epoxy cembr 8E ,15(17) dien 16 ,3 olide(5 )。还利用1 H 1 HCOSY ,HMQC ,HBMC二维谱首次对dihydroflexibilide(1)所有的1HNMR和13 CNMR信号归属作了指定。测定了 1、2和 3的细胞毒性更多还原

【Abstract】 The chemical constituents of marine soft coral Sinularia tenella Li. collected from Hainan Sanya are reported herein for the first time. Five cembrenolides ,i. e., dihydroflexibilide,flxibilide ,sinulariolide,(1 R,4R,5R,8S,9S,12S,13S ) 9 acetoxy 5,8∶12,13 diepoxy cembr 15(17) en 16,4 olide and (1 R,4R,5S,12S,13S ) 5 acetoxy 12,13 epoxy cembr 8 E ,15(17) dien 16,3 olide were isolated and identified by means of spectroscopic method. Base on the 1H 1H COSY,HMQC and HBMC experiments, all the 1HNMR and the 13 C NMR signals of dihydroflexibilide were assigned for the first time in this paper.更多还原