【摘要】 目的　探讨异种肝细胞移植治疗暴发型肝衰的疗效。方法　杂种豚鼠为供体 ,胶原酶消化法制备肝细胞。SD大鼠为受体 ,D 氨基半乳糖 (D GI)腹腔内一次注射制作肝衰模型。 48小时后将豚鼠肝细胞 (1 5× 10 7个 )移植于大鼠脾内。同种移植及生理盐水为对照。移植后观察受体二周存活率 ,在不同时间作移植物病理及组织化学检查。结果　受体 2周存活率 :异种移植组 71% ,同种组 6 8% (P >0 0 5 ) ,生理盐水对照组 2 5 % (P <0 0 1)。豚鼠肝细胞移植后 12～ 2 4小时其结构和功能基本保存完好。结论　与同种移植一样 ,异种肝细胞移植能逆转大鼠暴发型肝衰更多还原

【Abstract】 Objetive Toobservetheefficacyofxenogenichepatocytetransplantaion(XHX)inatoxicmodeloffulminanthepaticfailue(FHF)inrat.Method SDrats(n =14)thatreceived 1 5× 10 7 guinea pighepatocyteintraspleenat 48hoursafterD galactosamine (D GI)intraperitnearinjection(1 95mg/kg) .Thetwoweeksurvivalratewascomparedwithsyngenichepatocytetransplantation(n =16 )andcontrolanimals(n =16 ) .Thepathologicalexaminationsweredoneatthedifferenttimeaftertrans plantion .Results TheXHTwasabletosignificantlyimprovesurvivalrateasSHTdone(71%versus 6 8% ,P >0 0 5 )whencomparedwithfunctionsofguineapighepatocytestransplantedwerebasicllynormalduringthetimeof 12 2 4hoursaftertransplantation .Conclusion XHTcouldreversetheFHFofratin ducedbyD GI更多还原