【摘要】 目的　了解中药川芎嗪对严重烧伤早期脏器功能的保护作用。方法　临床选择烧伤面积 >30 % (小儿 >15 % )、入院时己发生休克或休克代偿期 80例 ,其中 40例在用平衡盐溶液复苏的同时静脉注射中药川芎嗪 (80～ 12 0mg ,Bid) ,用药 72h ,为用药组 ;另 40例单纯用平衡盐溶液复苏者为对照组。对比观察休克缓解情况 ,7h后缓解者为休克延迟复苏 ;对比观察内脏并发症的发生率与病死率。结果　休克症状缓解情况 :用药组 ,6h内缓解者占 85 % ,7h后延迟复苏者占 15 % ;对照组 ,6h内缓解者占 2 5 % ,7h后缓解者占75 % ;严重并发症的发生率与病死率 :用药组为 2 0 %和5 % ;对照组为 5 7 5 %和 30 %。结论　严重烧伤后早期应用中药川芎嗪对脏器功能有很好的保护作用更多还原

【Abstract】 Objective To invastigate effect of ligustrazine on the main organs injury following burn. Methods 80 patients by adult being over 30% TBSA (child over 15% ) and being in hospital during shock stage,They were divided into 2 groups, in which 40 cases were simple fluid resuscitation group (SFR) and other 40 cases were ligustrozine treated group (LT), the group was taken fluid resuscitation at sometime injected ligustuszine (40 mg/kg, bid). Results There were strikingly reconditioned patients shock in LT group 65% within 6 h, 15% within 7 h; But in SFR group, there were strikingly reconditioned patients shock 25% within 6 h, 75% within 7 h. There were 20% incidence of severe complication and 5% mortality in LT group; while in SFR group, 57.5% incidence of complication and 30% mortality. Conclusion Ligustrozine can protect main organ from injury following burns.更多还原