【摘要】 目的　探讨创面 pH值对碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)促进烧伤创面愈合作用的影响。方法　 1998年 10月～ 1999年 12月我科 47例住院患者 6 0处深Ⅱ度创面喷用bGFG ,再常规使用敷料包扎 ,利用精密pH试纸动态监测创面 pH值 ,根据创面平均 pH值分为酸性组和碱性组 ,观察创面完全愈合的时间并探讨其与pH值之间的相关性。结果　创面平均pH值变化在 5 4～7 8之间 ,碱性组创面的愈合时间为 16 7天± 2 3天 ,酸性组为 19 5天± 2 5天 ,两者差异具有显著性 (P <0 0 5 ) ,且深Ⅱ度创面完全愈合的时间与创面的 pH值之间具有负相关性 (r =- 0 2 43 ,P <0 0 5 )。结论　适度的碱性环境可加强bFGF促进烧伤创面愈合的作用更多还原

【Abstract】 Objective\ To investigate the relation between burns wound healing enhancement of basic fibroblast growth factor(bFGF) and wound pH. Methods\ Sixty wounds of deep partial thickness burns in 47 inpatients were treated with bFGF from October,1998 to December,1999. Dynamic changes of wounds pH were examined by using precise litmus test paper. The wounds were divided into two groups:acid group and base group, according to the mean wound pH. The complete healing time of deep partial thickness burns wound and its correlation with wound pH were examined. Results\ The mean pH of burns wounds ranged from 5 4 to 7 8. After the application of bFGF,the complete healing time of deep partial thickness wounds was significantly shorter in base group than in acid group(16 7±2 3 days vs 19 5±2 5 days, P<0 05). The wounds pH was negatively correlated with the wound healing time (r=-0 243,P<0 05). Conclusion\ An appropriate basic condition may potentiate the wound healing enhancement of bFGF.更多还原