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种衣剂的急性毒性及致敏性实验研究
Study on the acute toxicity and contact allergenic activity of 6 seed treatment preparations
【摘要】 目的 了解几种常见类型种衣剂的急性经口、经皮毒性、急性皮肤刺激及眼刺激作用、皮肤致敏作用 ,为混配种衣剂的危险度评定及中毒的防治提供科学依据。方法 按国家标准GB15 6 70 1995进行。结果 3种含克百威的混配种衣剂大鼠经口LD50 为 6 8 1~ 2 71mg·kg-1,属中等毒 ,其中两种种衣剂大鼠经皮LD50 为 5 11~ 2 0 0 0mg·kg-1,属中等毒 ;其余大鼠经口、经皮毒性均为低毒 ;受试种衣剂有不同程度的眼刺激性和皮肤致敏作用 ,有轻度或无皮肤刺激性。结论 种衣剂的较高急性毒性与其高毒的杀虫剂成分有关 ,其对皮肤和眼睛的作用应引起重视。提示应合理混配、大力推广高效低毒的农药 ,加强混配种衣剂生产和使用中的安全防护
【Abstract】 Objective To study the acute oral, dermal toxicity and ophthalmol, skin irritation effects and the contact allergenic activity of 6 seed treatment preparations. Methods The experiments were done according to GB 15670 1995. Results For 3 samples, the acute oral toxicity (LD 50 ) on SD rats was between 68 1~271 mg·kg -1 , the acute dermal toxicity (LD 50 ) on SD rats was between 511~ 2 000 mg·kg -1 respectively. For the others, the acute oral and dermal toxicity of was graded as low. For 6 samples, the ophthalmol irritation on New Zealand rabbits was graded as low to median. The allergenic rates of 3 samples were shown to be 20%~50%. Conclusion The oral, dermal toxicity of seed treatment preparations were graded as low to median. The 3 samples appeared to be week or median allergens. The effective prevention should be stressed for the occupational poison of seed treatment preparations.
- 【文献出处】 安徽医科大学学报 ,Acta Universitis Medicinalis Nahui , 编辑部邮箱 ,2001年04期
- 【分类号】R99
- 【被引频次】4
- 【下载频次】81