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L-四氢巴马汀对吗啡依赖大鼠阿片肽含量的影响

Effects of L-tetrahydropalmatine on opioid peptides contents in morphine dependent rats

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【作者】 葛晓群林安平孙云周华珠张洪泉卞春甫

【Author】 GE Xiao Qun, LIN An Ping, SUN Yun, ZHOU Hua Zhu 1, ZHANG Hong Quan, BIAN Chun Fu 2 (Dept of Pharmacology, 1Dept of Nursing, Medical College,Yangzhou University, Yangzhou 225002)2( dept of pharmaclolgy, xuzhou medical college,xuzhou 221002

【机构】 扬州大学医学院药理学教研室!扬州225002扬州大学医学院护理学教研室!扬州225002徐州医学院药理学教研室!徐州221002

【摘要】 目的 观察L 四氢巴马汀 (L THP)对吗啡依赖大鼠血浆、下丘脑 β EP和纹状体LEK含量的影响。 方法 用放射免疫法测定 β EP和LEK含量。 结果 L THP 40mg·kg-1ip可拮抗吗啡依赖大鼠 β EP释放减少的作用 (P <0 0 1)。与自然戒断组比较 ,L THP可显著加速血浆中 β EP水平的恢复 (P <0 0 5 ) ,并部分拮抗戒断 2d时下丘脑 β EP含量的下降 (P <0 0 5 ) ,对纹状体LEK含量无影响。结论 L THP能促进吗啡依赖大鼠 β EP释放 ,这可能是它抑制吗啡戒断症状的机制之一。

【Abstract】 AIM To observe the effects of L tetrahydropalmatine ( L THP) on β endorphin (β EP) contents in plasma and hypothalamus and leucine enkephalin (LEK) contents in striatum in morphine dependent rats. METHODS The contents of β EP and LEK were measured with radioimmunoassay. RESULTS In the rats with morphine dependence, the decrease of contents of β EP in plasma induced by morphine was antagonized significantly by ip injection of L THP 40 mg·kg -1 ( P <0 01). As compared with those in natural withdrawal rats, L THP accelerated greatly the rise in β EP level of plasma ( P <0 05) and increased the contents of β EP in hypothalamus 2 d after withdrawal ( P <0 05), though LEK contents in striatum did not change significantly. CONCLUTION L THP can stimulate the release of β EP in morphine dependent animals, which may be one of mechanisms inhibiting the withdrawal syndromes of morphine.

【关键词】 吗啡依赖四氢巴马汀内啡肽下丘脑血浆
【Key words】 morphinedependencetetrahydropalmatineendorphinhypothalamusplasma
【基金】 江苏省教委自然科学基金!资助课题 ;No 98KJB3 10 0 0 8
  • 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,2001年03期
  • 【分类号】R965
  • 【被引频次】11
  • 【下载频次】71
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