【摘要】 目的 :比较进口与国产碳酸钙片对维持性血液透析病人高磷血症的血磷水平的影响。方法 :75例维持性血液透析病人在参加实验前曾经规律服用国产碳酸钙片 6mo以上。参加实验后 38例用进口碳酸钙 (进口组 )代替国产碳酸钙 ,另外 37例维持原治疗 (国产组 ) ,服药 3mo后 ,计算 2组病人服药前 3mo和服药后 3mo平均的血钙、血磷浓度 ,计算钙磷乘积。结果 :进口组服药后 3mo ,血钙的差值为 ( 0 .15± 0 .0 9)mmol·L 1,国产组为 ( 0 .0 6±0 .13)mmol·L 1,均P <0 .0 1,2组间差值比较P <0 .0 1。血磷分别为 ( - 0 .5± 0 .3)mmol·L 1和( - 0 .15± 0 .2 8)mmol·L 1,2组间差值比较P <0 .0 1。结论 :进口碳酸钙降血磷优于国产品更多还原

【Abstract】 AIM:To compare effects of imported and domestic calcium carbonate on serum phosphorus level in patients with hemodialysis. METHODS:Seventy five patients with hemodialysis were divided into two groups. Group A( n =38, M 23, F 15; age 49 a± s 11 a) was treated with imported calcium carbonate 1250 mg, po , bid for 3 mo. Group B( n =37, M 20, F 17; age 50 a±12 a) was treated with domestic calcium carbonate 750 mg, po , tid for 3 mo. Before and after treatment, the serum calcium and serum phosphorus of all the patients were examined. RESULTS: After 3 mo, the difference of serum calcium of group A before and after treatment was (0.15±0.09) mmol·L 1 ( P <0.01), while that of group B was (0.06±0.13) mmol·L 1 ( P <0.01). There was a significant difference between the two groups ( P <0.01). The difference of serum phosphorus of group A before and after treatment and that of group B were (-0.5±0.3) mmol·L 1 and (-0.15 ±0.28) mmol·L 1 ( P <0.01), respectively. There was a significant difference between the two groups ( P <0.01). CONCLUSION: Imported calcium carbonate is more effective in decreasing serum phosphorus than domestic one.更多还原