【摘要】 目的 :观察红色诺卡菌细胞壁骨架 (N CWS)胸腔内注射治疗恶性胸腔积液的临床疗效。方法 :60例恶性胸腔积液病人行胸腔闭式引流尽量放尽胸液后分成 2组 ,N CWS组 30例 ,男性 19例 ,女性 11例 ,年龄 62a±s 11a ,将N CWS每次 4 0 0～ 60 0 μg溶于氯化钠注射液 2 0mL ,注入胸腔内 ,qw ,连续 2次 ;薏苡仁组 30例 ,男性 17例 ,女性 13例 ,年龄 63a± 10a ,将薏苡仁注射液每次 10 0～ 2 0 0mL ,注入胸腔内 ,qw ,连续 2次 ,观察胸腔积液控制效果及其不良反应。结果 :N CWS组有效率为87% ,薏苡仁组为 57% ,2组差异有显著意义 (P <0 .0 5)。结论 :N CWS治疗恶性胸腔积液效果较薏苡仁注射液佳。更多还原

【Abstract】 AIM: To observe the clinical efficacy of Nocardia rubra cell wall skeleton (N CWS) in the treatment of malignant pleural effusion by intrapleural injection. METHODS: Sixty patients with malignant pleural effusion were divided into two groups. In N CWS group, 30 patients (M19, F11; age 62 a± s 11 a) were treated with N CWS 400 600 μg in 20 mL sodium chloride injection, intrapleural injection, qw for 2 wk. In coixlipid group, 30 patients (M17, F13; age 63 a±10 a) were treated with injectable coixlipid, intrapleural injection, 100 200 mL qw, for 2 wk. RESULTS: In N CWS group, the responsive rate was 87% while comparing to 57% in coixlipid group, which has statistical significance ( P <0.05). CONCLUSION: In the treatment of malignant pleural effusion, N CWS has showed much evident efficacy than in jectable coixlipid.更多还原