【摘要】 目的 :观察利洛司酮对大鼠异位子宫内膜的抑制作用。方法 :用外科自体移植术建立大鼠子宫内膜异位症模型。灌胃给药 ,qd× 2 1d ,测量给药前、后异位内膜体积 ,计算药物对异位内膜的抑制率。结果 :用药后对照组大鼠异位子宫内膜比用药前略增大 ;给予利洛司酮 2 0 ,80mg·kg- 1和米非司酮 50mg·kg- 1后 ,异位内膜的体积比用药前明显缩小 ,抑制率依次为 (80± 2 7) % ,(88± 2 2 ) %和 (82± 31) %。结论 :利洛司酮和米非司酮一样明显抑制大鼠异位子宫内膜的生长更多还原

【Abstract】 AIM: To observe the inhibitory effect of lilopristone (Lil) on the growth of endometrial explants in rat model of endometriosis. METHODS: The model of endometriosis in rats was made by surgically autotransplanting endometrium to the peritoneum. After 3 wk, rats were laparotomized and the volumes of endometrial explants were measured. One week after second laparotomy, Lil 20, 80 mg·kg -1 , mifepristone (Mif) 50 mg·kg -1 and solvent 4 mL·kg -1 were given intragastrically (ig) qd for 21 d. At the end of treatment the volumes of endometrial explants were measured again. The inhibitory rates of the drugs on the ectopic endometrium were calculated. RESULTS: In Lil 20, 80 mg·kg -1 and Mif 50 mg·kg -1 treated rats, the growth of endometrial explant was inhibited significantly ( P < 0.01 ), with inhibitory rates of (80±27) %,(88±22) % and (82±31) %, respectively. CONCLUSION: As Mif, Lil could inhibit the growth of ectopic endometrium in rat model of endometriosis.更多还原