【摘要】 目的 :考察头孢吡肟与 0 .5%甲硝唑配伍的稳定性。方法 :用紫外双波长、系数倍率法分别测定头孢吡肟与甲硝唑的含量。结果 :在 0 ,1,2 ,4 ,6h内 ,2药合用的含量、pH及外观基本不变。该方法的平均回收率头孢吡肟为 (10 0 .9± 0 .4 ) % (n =5) ,甲硝唑为 (99.8± 0 .6 ) % (n =5)。结论 :2种药物配伍 6h内基本稳定。用双波长、系数倍率法分别测定其稳定性 ,方法简便、准确、实用性广。更多还原

【Abstract】 AIM: To study the compatible stability of cefepime with 0.5% metronidazole injection. METHODS: Dual wavelength spectrophotometry and K-ratio spectrophotometry were described for the determination of cefepime with metronidazole injection during 6 h. RESULTS: There was no evident variation in content during 6 h at room temperature. The average recovery rates of cefepime and metronidazole were (100.9±0.4)% and (99.8± 0.6)% ( n =5). CONCLUSION: The compatiblity of cefepime with metronidazole injection is stable. The method of using dual wavelength spectrophotometry and K ratio spectrophotometry to determine the compatible stability of cefepime with metronidazole is simple, accurate and usable. The graduate of Guangdong Pharmacy College, Guangzhou GUANGDONG 510224更多还原