【摘要】 目的 :比较头孢他美酯与头孢克肟治疗急性细菌性感染的安全性、有效性。方法 :多中心随机对照开放临床试验 ,头孢他美酯组 98例 (男性 4 3例 ,女性 55例 ,年龄 4 0a±s 13a) ,用头孢他美酯2 50～ 50 0mg ,po ,bid ,头孢克肟组 95例 (男性 4 4例 ,女性 51例 ,年龄 4 2a± 14a) ,用头孢克肟 2 0 0mg ,po ,bid ,疗程均为 7～ 14d。结果 :2组临床总有效率分别为 95%与 94 % ,细菌清除率分别为96%与 94 % ,细菌高度敏感百分率分别为 98%与96% ,不良反应发生率分别为 7%与 6% ,经统计学处理差异均无显著意义 (P >0 .0 5)。结论 :头孢他美酯与头孢克肟治疗急性细菌性感染安全、有效更多还原

【Abstract】 AIM: To evaluate the safety and efficacy of cefetamet pivoxil vs cefixime in the treatment of acute bacterial infections. METHODS: A multicenter randomized controlled clinical trial was conducted. Ninety eight patients (M 43, F 55; age 40 a± s 13 a) with acute bacterial infections of cefetamet group were given cefetamet pivoxil 250 500 mg, po , bid, for 7 14 d, and ninty five patients (M 44, F 51; age 42 a±14 a) of cefixime group were given cefixime 200 mg, po , bid, for 7 14 d. RESULTS: The overall clinical efficacy rates were 95 % and 94 %, the bacterial clearance rates were 96 % and 94 %, the bacterial sensitive rates were 98 % and 96 %, the adverse reaction rates were 7 % and 6 %, respectively. There was no statistical significance between two groups ( P >0.05). CONCLUSION: Cefetamet pivoxil and cefixime are effective and safe in the treatment of acute bacterial infections.更多还原