【摘要】 目的　探索云南省血吸虫病重度流行区化疗后维持巩固方案。方法　在原血吸虫病重度流行的坝区 ,经连续人、畜同步化疗后 ,选择居民感染率降至 8%左右的中和行政村。随机分为 A、B两组 ,各组约 10 0 0人。 A组 3～ 6 0岁人群每年用 IHA筛检约 6 0 0人 ,阳性者化疗 ,扩大化疗至 40 0人左右。B组每年用询检法筛检 3～ 6 0岁人群 ,确定化疗对象 40 0人左右。每年春秋两季各组在村庄周围及交叉路口周围环境查灭螺 1次 ,化疗 2 5 %的牛群 ,干预措施连续 2年。结果　 A组居民感染率下降 78.0 0 %,儿童感染率下降 6 4.40 %,钉螺自然感染率下降 16 .6 6 %,感染螺平均密度下降6 0 .0 3%。B组居民感染率下降 84.12 %,儿童感染率下降 78.77%,并且于第 2年秋季及效果考核时未发现阳性钉螺。结论　用 IHA筛检及询检法筛检各化疗 5 0 %人群。辅以村庄周围易感环境灭螺方案均可作为云南省重疫区连续化疗后的维持巩固措施 ,而且 B方案防治效果较好更多还原

【Abstract】 Objective To explore the better scheme of maintenance and consolidation after schistosomiasis chemotherapy in heavy endemic areas in Yunnan Province.Methods The study area was Zhonghe Administrative Village in basins among mountains where it was a former heavy endemic area of schistosomiasis japonica, and the infection rate of residents has been reduced to about 8% by synchronization of chemotherapy in people and cattle. The village has been divided randomly into two groups: A and B ( about 1000 persons in each group). Six hundred residents of 3～60 years old in Group A were screened by IHA annually. Persons whose IHA>1∶10 were treated with praziquantel and the expanded mass chemotherapy has amounted to about 400 persons. Residents who were 3～60 years old in Group B have been screened annually by inquiring examination and about 400 persons were defined as chemotherapy objects and were treated with praziquantel. Snails in high transmission areas around the village in both groups of A and B were detected and eradicated in spring and autumn every year. Twenty five percent of cattle in each group were treated with praziquantel powder annually. Above intervention measures have been kept up 2 years. [WT5”HZ]Results [WT5”BZ]The infective rate of residents in Group A has been reduced by 78.00%, the infective rate of children has been reduced by 64 40%, infective rate of snails has been reduced by 16 66% and the density of infective snails has been reduced by 60 03% The infective rate of residents in Group B has been reduced by 84 12%, the infective rate of children has been reduced by 78 77%, and the infective snails have not been found in the investigation in autumn of the second year.Conclusion Both schemes above mentioned can be treated as the measures of maintenance and consolidation after schistosomiasis chemotherapy in heavy endemic areas in Yunnan Province, and the effectiveness of scheme in Group B is better.更多还原