【摘要】 目的观察爱康宁胶囊体外抗肿瘤活性及毒副作用。方法采用双层琼脂集落形成实验观察爱康宁胶囊的体外抗癌作用 ,并作急性毒性限量实验观察爱康宁胶囊的毒性作用。结果爱康宁胶囊对人癌细胞 (肝癌BEL -74 0 2、胃腺癌MGC -80 -3和食管癌Eca1 0 9)有明显的细胞毒作用。小鼠腹腔注射LD50 为 39.8± 4 .5 g/kg ,急性毒性限量试验小鼠口服 6 0 0 g/kg·d ,连用 7d ,无明显毒性。 结论爱康宁胶囊可通过直接杀灭癌细胞而发挥显著的抗肿瘤作用 ;对机体毒性小。更多还原

【Abstract】 Objective To study the cancer-fighting activity in vitro and toxicity of Aikangning Capsules.Methods The cancer-fighting activity were observed by agar plate method and the toxcity by acute maximal tolerance dose toxicity testing.Results Studies in vitro found Aikangning could produce obvious cytotoxicity on BEL-7402 human hepatocellular carcinoma cell,MGC-80-3 human gastric adenocarinoma cell and Eca109 human esophageal carcinoma cell.LD50 of Aikangning on mice for intraperitoneal administration was 39.8±4.5g/kg.The acute maximal tolerance dose toxicity testing found that Aikangning (600mg/kg·d po ×7) didn’t show obvious toxicity on mice.Conclusion Aikangning Capsules could produce obvious cancer-fighting effects by killing cancerous cell directly,showing less toxicity.更多还原