【摘要】 目的探讨VitB2 在兔角膜碱烧伤中的保护作用及其机制。方法复制兔右眼角膜碱烧伤模型 ,设实验组和烧伤组。实验组于烧伤后每日以VitB2 0 .2ml/kg球结膜下注射。烧伤组每日以等量生理盐水注射。分别于第 1 ,4 ,8,1 6 ,32及 6 4天测量各组角膜组织中丙二醛 (MDA)的含量及超氧化物歧化酶 (SOD)的活性。结果 :烧伤后的第 1 ,4 ,8,1 6 ,32天实验组MDA含量显著低于烧伤组 ,而SOD活性1— 6 4天明显高于烧伤组 ,尤其是第 4天至第 1 6天的差异具有统计学意义。结论 :VitB2 对角膜碱烧伤后角膜组织的恢复有明显的促进作用 ,其机理之一可能与其抗脂质过氧化损伤有关。更多还原

【Abstract】 Objective To research the effect of vitamin B 2 in corneal burn by alkali in rabbits.Method Copy the model of alkali burn in right eye cornea while the left eyes as normal control group.The model rabbits were divided into two groups treated with injection of vitamin B 2 and normalsaline from conjunctivite respectively,then the MDA level and SOD activity were measured.Results On the 4th,8th,and 32nd days after the burning,the MDA level of experimental group was markedly lower than that of burned group.And SOD activity of experimental group was also remarkably higher than that of burned group.Conclusion Vitamin B 2 has marked effects against corneal alkali burn,associated with its anti-lipid peroxidation actions.更多还原