【摘要】 目的探讨血管内皮生长因子 (VGEF)在胶质瘤微血管形成中的作用以及与胶质瘤生物学行为的关系。方法选择 4 5例脑胶质瘤手术标本 ,采用免疫组织化学方法测定血管内皮生长因子及Ⅷ因子相关抗原的表达。结果血管内皮生长因子在胶质瘤中的阳性表达率为 :Ⅰ级 :1 9.4± 4 .5 ,Ⅱ级 :2 4 .9± 1 5 .1 ,Ⅲ级 :5 3.8± 1 0 .7,Ⅳ级 70 .3± 1 0 .3,MVD的阳性率为 :Ⅰ级 :8.2± 1 .6 ,Ⅱ级 :8.8± 1 .7,Ⅲ级1 6 .6± 3.6 ,Ⅳ级 1 9.5± 6 .1 ,低度恶性 (Ⅰ -Ⅱ级 )与高度恶性 (Ⅲ -Ⅳ级 )有显著差异 (P <0 .0 5 )结论血管内皮生长因子能促进肿瘤中微血管形成 ,它与微血管密度均可作为脑胶质瘤恶性程度的重要指标。更多还原

【Abstract】 Objective To evaluate the function of expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) and to study the relationship between VEGF and the clinic characteristics of glioma.Methods The expression of VEGF and factor Ⅷ-related antigen in 45 patients with glioma were studied retrospetively by using immuohistochemical staining.Results The positive rate of VEGF in first group was 19.4±4.5,second group 24.9±15.1,third group 53.8±10.7 and fourth group 70.3±10.3,the positive rate of MVD in above groups was 8.2±1.6,8.8±1.7,16.6±3.3 and 19.5±6.1 respectively;between the low malignant groups (Ⅰ-Ⅱ) and high malignant groups (Ⅱ-Ⅲ) there were significant difference (P<0.05).Conclusion VEGF plays an important role in the microvessel growth of glioma and it would be significant predicting index of malignant degree.更多还原