【摘要】 目的研究黄芩煎剂对大鼠实验性肝损伤的保护作用及其机制。方法采用急性CCl4 肝损伤模型 ,设黄芩煎剂大、中、小剂量组、对照组和正常组 ,观察各组大鼠血浆中丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)和山梨醇脱氢酶 (SDH)活性变化。结果黄芩煎剂能降低血MDA含量和SDH活性 ,增加SOD活性 ,减轻肝损伤程度 ,且有明显的量效关系。结论黄芩煎剂具有良好的保护CCl4 致大鼠急性肝损伤的作用 ,其机理可能与抑制体内的过氧化反应有关更多还原

【Abstract】 Objective To research the mechanism and protective effect of huangqin elixation on liver injury induced by perchlormethane.Method The liver injury model was established by perchlor methane.The model rats were divided in 4 groups—three of them were respectively treated with high,middle and low dosage of huangqin elixalion,and another one as control.The 5th group was made as normal control.Measure the SDH,SOD activities and MDA level in serum in all groups.Results In three groups treated by huangqin elixation,the MDA level and SDH activity were obviously decreas and showed a remarkable dose relationsnip.Conclusion Huangqin elixation has good protective effect on rat with acute liver injury by perchlormethane,and the mechanism is probably relating to inhibiting the lipid peroxidation.更多还原