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EGF-R和C-erbB-2在前列腺癌中的表达及其相关性研究

The relationship of the expression of EGF-R and C-erbB-2 in prostate carcinoma

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【作者】 崔曙马彬杨建昆阿里木·塔来提木拉提·马合木提盛新福

【Author】 CUI Shu, MA Bin, YANG Jian-kun, et al (Department of Urology, Second Affiliated Hospital, Xinjiang Medical University,Urumqi 830028, China)

【机构】 新疆医科大学第二附属医院泌尿外科新疆医科大学第一附属医院泌尿外科 新疆乌鲁木齐830028新疆乌鲁木齐830028新疆乌鲁木齐830

【摘要】 目的:探讨 EGF- R(C- erb B- 1)和 C- erb B- 2在前列腺癌 (PCa)中的表达及其相关性。方法 :采用免疫组化 ABC法 ,分别对 2 9例前列腺癌患者进行了 EGF- R(C- erb B- 1)和 C- erb B- 2表达的研究。结果 :2 9例前列腺癌患者 ,EGF- R表达仅有 5例阳性 (17.2 % ,5 / 2 9) ,C- erb B- 2阳性表达有 13例 (4 4.8% ,13/ 2 9) ,阳性表达率之间有显著性差异 (P <0 .0 5 ) ;EGF- R阳性表达与肿瘤的临床分期及病理分级无显著性差异 (P >0 .0 5 ) ,而同时 C- erb B- 2的阳性表达与肿瘤的分期、分级有显著性差异 (P <0 .0 5 )。结论 :EGF- R表达与前列腺癌的临床分期和分级可能无关 ,而 C- erb B- 2表达与前列癌的临床分期和分级等因素可能有关。

【Abstract】 Objective: To study the relationship of the expression of EGF-R(C-erbB-1) and C-erbB-2 in prostate carcinoma (PCa). Methods: By means of immunohistochemical ABC method, we studied 29 cases of prostate carcinoma. Results: Staining for EGF-R was found in five of 29 PCa (17.2%), and this tissue in PCa was stained positiviely for C-erbB-2 in 44.8% (13/29). The expression of EGF-R and C-erbB-2 in PCa showed significant meaning (P<0.05) and no significant relationship was observed between tumor stage, grade and expression of EGF-R. Significant statistical meaning was observed between tumor stage, grade and expression of C-erbB-2. Conclusions: These findings demonstrated that the EGF-R expression might not associate with tumor stage and grade, but the C-erbB-2 expression might associate with other features of prognostic importance such as stage or grade.

【关键词】 EGF-RC-erbB-2前列腺癌
【Key words】 EGF-RC-erbB-2prostate carcinoma
【基金】 新疆医科大学科研启动基金资助项目 ( YQ-98-0 10 )
  • 【文献出处】 新疆医科大学学报 ,Journal of Xinjiang Medical University , 编辑部邮箱 ,2001年04期
  • 【分类号】R737.25
  • 【下载频次】26
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