【摘要】 目的　研究天然胡萝卜素对二甲基苯并蒽 (DMBA)诱发的金黄地鼠口腔粘膜癌前病变的逆转作用。方法　选用DMBA诱发金黄地鼠口腔粘膜癌前病变模型 ,用 0 .5 %天然胡萝卜素溶液灌胃口服和口腔局部贴膜进行治疗 ,光镜下组织观察。结果　无论是灌胃治疗组还是口腔贴膜组均显示出明显的治疗效果 ,灌胃治疗组略优于口腔贴膜组。结论　天然胡萝卜素对DMBA诱发的动物口腔癌前病变有逆转作用。更多还原

【Abstract】 Objective The reverting effects of natural carotene on dimethyl-benzanthracene (DMBA) induced oral premalignant lesion in syrian golden hamsters were studied.Methods The hamsters were divided into,control group of the oral premalignant epithelia,oral administration of natural carotene treated group (15mg/kg/day,5d/week,for 4 weeks) and topical application of membrane of natrual carotene treated group (1cm×1cm/10mg,5d/week,for 4 weeks).Results Both oral administration group and topital administration group showed effective,but oral administration group was a bit superior in treating oral premalignant lesion to topical administration.Conclusion Natural carotene could effectively revert DMBA-induced oral premalignant lesion in hamsters.更多还原