【摘要】 目的探讨血浆血小板激活因子乙酰水解酶pPAF-AH基因G994T突变与中国人群脑出血发病的相关关系。方法利用等位基因特异性聚合酶链反应技术分析了150例原发性脑出血病人和150例非脑血管病对照组pPAF-AH基因的基因型位点频率。结果T等位基因在脑出血组的频率是3%,在对照组是4%,GT杂合子在脑出血组和对照组频率分别为6.8%和8.5%,两组差异无显著意义。没有发现突变型的纯合子。结论pPAF-AH基因G994T突变与中国人群的脑出血没有明显的相关关系。更多还原

【Abstract】 Objective To investigate whether plasma platelet-activating factor acetylhydrolase (pPAF-AH) gene G994T mutation is associated with cerebral hemorrhage.Methods The genotype of pPAF-AH gene was analyzed in 150 patients with primary cerebral hem-orrhage and 150 controls without cerebral vascular disease with allele specific polymerase chain reaction. Results The freqencies of T allele were 3% in cerebral hemorrhage group and 4% in control group. GT heterozygote frequency in case and control group was 6.8% and 8.5% respectively.The difference between two groups was not significant. Conclusion These results suggested that pPAF-AH gene G994T mutation might not have any significant relationship with cerebral hemorrhage.更多还原