【摘要】 目的 :观察和比较静脉注射地尔硫 艹卓 、心律平控制阵发性室上性心动过速心室率的即时疗效和安全性。方法 :5 6例阵发性室上性心动过速患者 ,采用随机方式分两组 ,分别静脉注射地尔硫 艹卓 、心律平。结果 :两组控制阵发性室上性心动过速的快速心室率总有效率分别为 91.6 % ,6 6 .6 % ,心室率平均下降幅度分别为 44% ,35 % ,平均起效时间分别为 ( 7.8±4.5 )分钟、 ( 2 6 .5± 19.8)分钟。地尔硫 艹卓 组出现可耐受性低血压 2例 ,发生窦性停搏 1例 ,均可自行缓解 ,无心力衰竭加重表现 ;心律平组出现 2例可耐受性低血压 ,1例 度 型房室传导阻滞 ,1例窦性心动过缓。结论 :静脉注射地尔硫 艹卓 较心律平更能迅速、安全、有效地控制阵发性室上性心动过速的快速心室率。更多还原

【Abstract】 Objective: It is to observe the efficacy and safety of intravenous diltiazem and propafenonum in the control of ventricular rate of paroxysmal supraventricular tachycardia (PST). Methods: Fifty-six patients with PST were randomly divided into two groups. Intravenous diltiazem and propafenonum were respectively offered to the patients of the two groups. Results: The total efficacy rates were 91.6% and 66.6% respectively with a mean decrease in heart rate by 44% and 35% of the baseline in the two groups, while the mean times of response were 7.8±4.5 time and 26.5±19.8 time. Two patients developed asymptomatic hypotension and one case had sinus arrest in diltiazem group. All events were resolved without pharmacological treatment. No patient developed worsening of congestive heart failure due to diltiazem. Two patients developed degree-Ⅱ type-Ⅱ auriculo-ventricular block and sinus bradycardia respectively in propafenonum group. Conclusion: Diltiazem is safe and rapidly effective in acutely slowing of rapid ventricular rate on PST compared with propafenonum.更多还原