【摘要】 目的 :评估一种新的加强药物流产方案的效果。方法 :将孕 4 2～ 56d的 168例按孕周随机分组 ,研究组 84例予以甲氨蝶呤 (MTX)和睾酮辅助的加强药物流产处理 ,对照组 84例 ,予以睾酮辅助的药物流产处理。结果 :研究组血 β -hCG和孕酮水平下降速度较快 (P <0 .0 5) ,清宫率为 1.3% ,低于对照组的 9.1% (P <0 .0 5) ,流产成功率为 69.7% ,高于对照组的 50 .7% (P <0 .0 5) ,出血持续少于 2 2d者占 76.7%低于对照组的 60 .5% (P<0 .0 5) ,用药后血白细胞数和消化道反应、转经天数和月经恢复延迟例数无增加。结论 :MTX和睾酮辅助的加强药物流产方案优于单纯睾酮辅助的常规药物流产方案 ,可用于有较高药流失败率和出血风险的高危药流对象更多还原

【Abstract】 Objective:To determine effect of a strengthened medical abortion regime.Methods:A stratified random controlled trial was performed in 168 women requesting an abortion at 42～56 days’ gestation.In the control group,eighty-four subjects were treated with medical abortion assisted with testosterone. Results:(1)The down velocities of serum β-hCG and progesterone per day during the lst two-weeks of the study group was faster than those in the control group(P<0.05);(2)Successful abortion rate of the study group is higher than that in the control group(69.7% vs 50.7%, P<0.05);(3)Followed surgical abortion rate in the study group was lower than that in the control group(1.3% vs 9.1%,P<0.05);(4)The subjects with the bleeding duration less than 22 days in the study group are more than those in the control group(76.7% vs 60.5%,P<0.05);(5)The drug side effects in gastrointestine or blood,the days for the menses return and the subjects with the menstruation delay in the study group is not more than those in the control group. Conclusions:The strengthened medical abortion regime assisted with MTX and TP is better than the routine regime and may be selected and used,as an individualized strengthened medical abortion regime for those with high-risk failure or bleeding in the early pregnancy termination.更多还原