【摘要】 目的 了解性病门诊中以生殖器溃疡为主要表现的疾病的病因。方法 取生殖器溃疡处分泌物进行涂片、培养、荧光定量PCR、暗视野显微镜和血清学检查,同时检测梅毒螺旋体（TP）、单纯疱疹病毒（HSV）、人类乳头瘤病毒（HPV）、杜克雷嗜血杆菌（HD）及人类免疫缺陷病毒（HIV）。结果 在181例病人中,梅毒48例、生殖器疱疹32例、尖锐湿疣9例,分别占26.52％（48/181）、17.68％（32/181）、4.97％（9/181）和 0.55％（1/181）。其中梅毒合并生殖器疱疹6例,占3.31％（6/181）,合并尖锐湿疣1例,占0.55％（1/181）,合并HIV感染1例,占0.55％（1/181）;生殖器疱疹合并尖锐湿疣4例,占2.21％（4/181）;念珠菌6例,占 3.31％（6/181）,合并梅毒2例,占1.10％（2/181）;细菌7例,占3.87％（7/181）,合并梅毒4例,占2.21％（4/181）;未发现软下疳。79例未检出病原体,占43.65％（79/181）。结论 在性病门诊中,生殖器溃疡性疾病的病因以梅毒和生殖器疱疹为主,其次是尖锐湿疣,且存在混合性感染。更多还原

【Abstract】 Objective To investigate the etiology of genital ulcer diseases(GUD) in sexually transmitted disease(STD) clinics. Methods The specimens taken from 181 patients with genital ulcer attending STD clinics were detected for trepone-ma pallidum(TP), herpes simplex virus(HSV), human papillomavirus(HPV), haemophilus ducreyi and human immuno-deficiency virus(HIV) by fluorescent quantitative polymerase chain reaction (QF-PCR), dark field microscopy (D-F) and serological tests (ST).Results There were 48(26.52% ) cases of syphilis, 32 (17.68 %) cases of genital herpes, 9(4.97% ) cases of condylomata acuminata, 1(0.55%) cases of HIV, 6(3.31% ) cases of candidiasis, 7(3.87% ) cases of bacterial infection, 12(6.63% ) cases of co-infection among the 181 patients, respectively.No chancroid case was found. Indeterrminate pathogens were identified in remaining 79(43.65% )patients.Conclusion Syphilis and genital herpes were the predominant causes of GUD in STD clinics.更多还原