【摘要】 目的　探讨GM1 对脑卒中患者的脑保护作用。方法　将脑卒中患者分为常规治疗组及加用GM1 治疗组 ,以RIA法动态监测患者的血清神经元特异性烯醇化酶 (NSE)。结果　脑卒中患者两组血清NSE均于病后 48h～ 9d较对照组明显升高 (P <0 0 5 ,P <0 0 1 ) ,且均在病程 3～ 4d达高峰 ,随后逐渐下降 ;常规治疗组血清NSE在病后 1 0～ 1 4d恢复正常 ,而加用GM1 治疗组血清NSE则在 3～ 1 4d较常规治疗组相应病期低 (P <0 0 5 ,P <0 0 0 1 ) ,且提前降至正常。结论　动态监测血清NSE有助于观察脑卒中患者病情的变化 ;GM1 可能通过减轻神经元的继发损伤 ,降低血清NSE ,从而起到脑保护作用。更多还原

【Abstract】 Objective To evaluate the effect of GM 1 on the patients with stroke. Methods Serum NSE was measured by using RIA method in 3 groups: General therapy group, GM 1 therapy group(40～60 mg/d, 7～14 d) and control group.Results The results showed serum NSE was higher significantly in patients with stroke than that of controls in 48h～9 d ( P <0.05, P <0.01). The NSE level was the highest in 3～4 d, and then reduced gradually in stroke groups. In general therapy group, the NSE arrived to normal level in 10～14 d, but in GM 1 group, the NSE level was lower than that of general therapy level in 3～14 d( P <0.05, P <0.01) and recovered faster.Conclusion The test of serum NSE level is useful to monitor the course of the disease in stroke; GM 1 may reduce the serum NSE by decreasing the secondary injury of neuron, so as to protect brain.更多还原