【摘要】 :采用体外培养技术 ,模拟体内肿瘤转移过程 ,研究共轭亚油酸 (conjugated linoliec acid,CL A)对鼠黑色素瘤 B16 - MB高转移细胞系的转移特性 ,从而探讨 CL A预防肿瘤转移的可能途径。研究结果表明 ,剂量为 10 0 μmol/ L、2 0 0 μmol/ L 的 CL A可抑制肿瘤细胞增殖、恢复肿瘤细胞间通讯功能、抑制肿瘤细胞向细胞外基质成分 [层粘连蛋白 (fibronectin,FN)和纤维粘连蛋白 (laminin,L N) ]的黏附。更多还原

【Abstract】 In order to explore the effects of conjugated linoleic acid on tumor metastasis, the proliferation, gap junction intercellular communication(GJIC), adhesion to extracellular matrix, and metastasis cascades of tumor cells were imitated in cell culture. The results showed that 100 and 200μmol/L conjugated linoleic acid could inhibit the proliferation and the adhesion of tumor cells to extracellular matrix,and could recover its gap junction intercellulor communication.更多还原