【摘要】 目的　探讨胰岛素样生长因子Ⅱ (IGF Ⅱ )在肝硬化病人血清中的变化及临床意义。同时探讨IGF Ⅱ和透明质酸(HA)之间的关系。方法　肝硬化患者 80例 ,对照组 77例 ,应用放射免疫法检测空腹IGF Ⅱ和HA。结果　肝硬化患者血清中的IGF Ⅱ水平明显低于对照组 ( 162 0 5± 10 3 84ng/mlvs 5 75 .31± 194.87ng/ml,P <0 .0 0 1) ,肝硬化患者血清中HA水平明显高于对照组 ( 415 18± 2 88 2 8ng/mlvs 61.75± 2 8.68ng/ml,P <0 .0 5 ) ,且患者IGF Ⅱ水平与预后呈正相关。结论　IGF Ⅱ水平可反应肝功能的剩余能力 ,也可作为动态观察肝功能变化的指标之一 ,有助于疗效判断和预后估计。更多还原

【Abstract】 Aim To investigate the clinical significance of IGF Ⅱ and the relationship between insulin like grouth factor Ⅱ (IGF Ⅱ) and hyaluronate acid (HA) in patients with cirrhosis.Methods Eighty patients with cirrhosis and 77 controls were selected.IGF Ⅱ and HA in serum were detected using radioimmunoassays.Results Serum IGF Ⅱ level in cirrhosis were significantly lower than that in the controls(162 05±103 84 ng/ml vs 575.31±194.87 ng/ml, P <0.001).Serum HA level in cirrhosis were significantly higher than that in the controls (415 18±288 28 ng/ml vs 61.75±28.68 ng/ml, P <0.05),IGF Ⅱ level in cirrhotic was related to prognosis.Conclusions Serum IGF Ⅱ level not only can be used as a indicator of remain function of liver but also play an important role in prognosis.更多还原