【摘要】 目的　探讨胃癌发生发展过程中患者细胞免疫功能的变化。方法　采用流式细胞技术 (FCM )检测了 30例慢性浅表性胃炎 (CSG)、2 7例慢性萎缩性胃炎 (CAG)、42例胃癌 (GC)患者的外周血T 淋巴细胞亚群 (CD3+、CD4+、CD8+、CD4+/CD8+)及自然杀伤 (NK)细胞 ,并与正常对照相比较。结果　与正常对照相比 ,CSG患者外周血CD3+、CD4+明显下降 (P <0 0 5 ) ;CAG患者CD3+、CD4+、CD4+/CD8+、NK细胞与正常对照和CSG患者相比均有显著降低 (P <0 0 5～ 0 0 1) ;与CAG患者相比 ,胃癌患者CD3+、CD4+、CD4+/CD8+、NK各值进一步下降 (P <0 0 5～ 0 0 1) ,并与胃癌进展相关。结论　胃癌和癌前病变患者细胞免疫功能低下 ,对胃癌的发生发展具有重要意义。更多还原

【Abstract】 Aim To inquire into the variations of the patients’ cellular immunity in different stages of gastric carcinogenesis and tumor progression.Methods The T lymphocyte and natural killer cell(NK) in peripheral blood were determined by flow cytometrical analysis(FCM) in 30 cases of chronic superficial gastritis(CSG),27 of chronic atrophic gastritis(CAG) and 42 of gastric cancer(GC) The data were compared with 20 cases in normal control.Results The CD3 +,CD4 + in CSG patients were significantly lower than those in normal control group( P <0 05);the CD3 +,CD4 +,CD4 +/CD8 + ratio and NK cells were significantly lower in CAG patients than those in normal controls and CSG patients ( P <0 05～0 01);compared with CAG patients,the CD3 +,CD4 +,CD4 +/CD8 + ratio and NK cells were remarkably decreased ( P <0 05～0 01)in GC patients and were correlated with the tumor progression.Conclusion The capacity of cellular immunity in gastric cancer and precancerosis is lower,which plays an important role in the carcinogenesis and progression of gastric cancer.更多还原